Woodrose seeds effects
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
|Total||5 – 10 hours|
|Onset||30 – 180 minutes|
|Peak||2 – 7 hours|
|Offset||1 – 3 hours|
|After effects||3 – 24 hours|
DISCLAIMER: PW’s dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Lysergic acid amide (also known as ergine, d-lysergic acid amide, d-lysergamide, and LSA) is a naturally-occurring psychedelic substance of the lysergamide class. LSA is an ergot alkaloid and the main psychoactive constituent of morning glory seeds. [ citation needed ] LSA is chemically related to LSD and is said to produce similar effects, although the extent to which it does is unclear.
LSA was first described in 1932 as part of an investigation into the alkaloids found in ergot.  In 1947, it was synthesized and tested for human activity by Albert Hofmann. The intramuscular administration of a 500 microgram dose produced a “tired, dreamy state with an inability to maintain clear thoughts.”  In 1970, LSA was detected as a constituent in Hawaiian baby woodrose seeds, which were being ground up into capsules and sold on the street as “mescaline”.  Today, LSA is typically consumed via morning glory and Hawaiian baby woodrose seeds. 
User reports describe the effects of LSA as primarily sedating and dream-like, with a mild to moderate psychedelic component. The psychedelic effects of LSA occur inconsistently and are not directly comparable to the effects of classical psychedelics like LSD, psilocybin mushrooms, or mescaline. LSA is described as primarily bodily and cognitive with little visual effects. Many users report serious nausea and bodily discomfort (“body load”) when taking LSA-containing seeds.
Like other psychedelics, LSA is not considered to be addictive.  However, adverse reactions such as severe anxiety, paranoia, and psychosis are always possible, particularly among those who are predisposed to psychiatric disorders.  It is therefore highly advised to use harm reduction practices if using this substance.
- 1 Chemistry
- 2 Pharmacology
- 3 Subjective effects
- 3.1 Physical effects
- 3.2 Visual effects
- 3.2.1 Enhancements
- 3.2.2 Distortions
- 3.2.3 Geometry
- 3.2.4 Hallucinatory states
- 3.3 Cognitive effects
- 3.4 Auditory effects
- 3.5 Transpersonal effects
- 3.6 Combination effects
- 3.7 Experience reports
- 4 Natural plant sources
- 4.1 Morning glory seeds (MGS)
- 4.2 Hawaiian baby woodrose seeds (HBWR)
- 4.3 Preparation methods
- 5 Toxicity and harm potential
- 5.1 Vasoconstriction
- 5.2 Dependence and abuse potential
- 5.3 Dangerous interactions
- 5.4 Other interactions
- 6 Legal status
- 7 See also
- 8 External links
- 8.1 Discussion
- 9 References
LSA, or d-lysergic acid amide, is an organic alkaloid belonging to the lysergamide class. The chemical structure of LSA contains a core structure of lysergic acid with an amine functional group bound to RN. The structure of lysergic acid is composed of a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline, an acetamide group is bound. LSA is additionally substituted at carbon 6 with a methyl group.
LSA is a chiral compound with two stereocenters at R5 and R8. LSA, also called (+)-D-LSA, has an absolute configuration of (5R, 8R). The three other stereoisomers of LSA do not have psychoactive properties. LSA is structurally analogous to LSD, with the exception being that LSA lacks the diethyl substitution of LSD at RN of its carboxamide group. It can be used as a precursor to LSD.
LSA’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience remains the subject of scientific investigation.
The notion that LSA is the primary psychedelic constituent in morning glory and Hawaiian baby woodrose seeds has been challenged as the effects of isolated synthetic LSA are reported to be only slightly psychedelic in nature. Therefore, it has been proposed that the overall experience may possibly be produced by a mixture of various lysergamide alkaloids (including iso-LSA and LSH) within these plant materials instead of a single psychoactive compound.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a literature based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be treated with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses are more likely to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include serious injury or death.
- Sedation – LSA is predominantly sedating; however, this can be setting dependent. For example, when taken in settings with large amounts of stimuli or during physically strenuous activities such as walking, running, climbing or dancing, LSA is capable of becoming stimulating and energetic. In contrast, when taken in calm environments such as darkened rooms with comfortable seating, it tends to be relaxing, sedating.
- Spontaneous bodily sensations – The “body high” of LSA can be described as a mild yet pleasurable and soft tingling sensation. This is largely noticed in high doses and is accompanied by strong waves of physical euphoria which are usually manifested spontaneously at different unpredictable points throughout the trip but can also maintain a consistent presence. Compared to LSD, the physical effects of LSA tend to predominate the experience relative to its visual and cognitive effects.
- Perception of bodily heaviness
- Physical euphoria – This effect is reported to be more readily able to be produced by LSA than LSD. However, it can be masked by strong, uncomfortable feelings of nausea and vasoconstriction, particularly when LSA-containing seeds are consumed directly before any extraction has been performed.
- Motor control loss – This effect becomes far more present at high doses than lower doses. It can be compared to the loss of motor control experienced with alcohol-induced inebriation and is strengthened by the perception of bodily heaviness.
- Temperature regulation suppression 
- Nausea – The nauseating effects of LSA is thought to be mostly caused by the other components of the seeds (e.g. morning glory, Hawaiian baby woodrose, etc.) and not LSA itself. Various extraction methods can be used to significantly reduce if not eliminate the nausea that can be produced by this substance. Anecdotal reports also suggest that ginger tea or cannabis may be helpful in counteracting nausea.
- Vasoconstriction  – LSA is commonly reported to produce strong and pronounced feelings of vasoconstriction. This varies in its intensity between individuals but is often considered moderately to extremely uncomfortable in comparison to other psychedelics. This effect is commonly reported to cause joint and limb pains.
- Increased heart rate
- Increased blood pressure or Decreased blood pressure  – LSA has been reported as being capable of producing both an increase and a decrease in blood pressure, sometimes alternating at different points in the experience, such as during the come up or offset, although it is unclear how much of this is dependent on the seeds and variations in alkaloid contents.
- Muscle contractions & Muscle relaxation
- Muscle spasms
- Headaches 
- Appetite suppression
- Gustatory enhancement
- Orgasm suppression
- Excessive yawning
- Pupil dilation
- Increased perspiration
- Difficulty urinating
- The visual effects of LSA are mostly present when large doses have been consumed. When compared to LSD and psilocin, the visual effects of LSA are proportionally mild in comparison to the intensity of its accompanying cognitive and physical effects.
- Colour enhancement
- Pattern recognition enhancement
- Visual acuity enhancement
- Frame rate enhancement
The visual distortions and alterations are significantly more simplistic than open eye distortions found with other psychedelics. The effects experienced are detailed below:
- Depth perception distortions
- Drifting(melting, breathing, morphing and flowing) – In comparison to other psychedelics, this effect can be described as mild but highly detailed and cartoon-like in appearance. The distortions are fast yet smooth in motion and fleeting in permanence. This is an inconsistently manifested effect with some people never reporting such effects.
- Colour shifting
- Scenery slicing
- Symmetrical texture repetition
The visual geometry produced by LSA can be described as more similar in appearance to that of 4-AcO-DMT and ayahuasca than LSD or 2C-B. It can be described through its variations as primarily intricate in complexity, abstract in form, organic in appearance, unstructured in organization, dimly lit, multicolored in scheme, glossy in shading, soft in edges, small in size, slow in speed, smooth in motion, rounded in corners, non-immersive in depth and consistent in intensity. At higher doses, it is significantly more likely to produce 8B geometry over 8A geometry.
LSA is capable of consistently producing a full range of high-level hallucinatory states when it is taken in large doses. However, the doses required to achieve these states are likely to produce very uncomfortable, and potentially dangerous, side effects. These states include:
- Transformations – These are extremely common within LSA and partially follow the content of the user’s current thought process.
- Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) – Unlike LSD, LSA consistently produces moderate to high level hallucinatory states in high doses. This particular effect can be compared to a lucid dream state. The hallucinations are more common within dark environments and can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, controllable and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
- External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) – This effect occurs far more rarely and infrequently than with other hallucinogens. However, they can occasionally occur at heavier dosages. They can be described through their variations as lucid in believability, autonomous in controllability, and solid in style.
- Peripheral information misinterpretation
- The cognitive effects of LSA are described by many as extremely relaxing yet lucid and clear-headed in style when compared to other commonly used psychedelics such as LSD or psilocin. Although it is primarily sedating, it can produce fast-paced bursts of thought and stimulation at random intervals. LSA produces a large number of psychedelic cognitive effects. The most prominent of these typical effects include:
- Analysis enhancement – This effect is introspection dominant.
- Anxiety or Anxiety suppression
- Conceptual thinking
- Cognitive euphoria
- Déjà vu
- Emotion enhancement
- Empathy, affection and sociability enhancement
- Increased music appreciation – Listening to music can strongly intensify the overall experience.
- Immersion enhancement
- Language suppression – Mild compared to language suppression on classical psychedelics like LSD.
- Increased sense of humor
- Laughter fits
- Memory suppression
- Ego death
- Novelty enhancement
- Autonomous voice communication
- Thought acceleration
- Thought connectivity
- Thought loops
- Time distortion
- Auditory enhancement
- Auditory distortion
- Auditory hallucinations
- Spirituality enhancement
- Existential self-realization – This effect is less common and reproducible than it is with classical psychedelics like LSD, psilocybin mushrooms, and mescaline.
- Unity and interconnectedness
- Cannabis – Cannabis can immensely intensify the sensory and cognitive effects of LSA. Extreme caution is advised when mixing these substances as it can significantly increase the chances of a negative psychological reaction like anxiety, confusion and psychosis. Those who use this combination are advised to start off with only a fraction of their usual cannabis dose and take long breaks between hits in order to avoid a negative reaction.
- Dissociatives – Dissociatives greatly enhance the cognitive, visuals and general hallucinatory effects of LSA. Dissociative-induced holes, spaces, and voids while under the influence of LSA have significantly more vivid visuals than dissociatives alone, as well as more intense internal hallucinations and correspondingly increased risk of confusion, delusions and psychosis.
- Alcohol – Alcohol’s central depressant effects can be used to reduce some of the anxiety and tension produced by LSA. However, alcohol can cause dehydration, nausea and physical fatigue which can significantly worsen the experience. If using alcohol, it is advised to pace oneself and drink just a fraction of the usual amount.
- Benzodiazepines – Depending on the dose, benzodiazepines can slightly to completely reduce the intensity of the cognitive, physical and visual effects of an LSA trip. They are very efficient at stopping “bad trips” at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose as they are very easy to abuse.
- Psychedelics – When used in combination with other psychedelics, each substance’s physical, cognitive and visual effects intensify and synergize strongly. The synergy between those substances is unpredictable, and for this reason generally not advised. If choosing to combine psychedelics, it is recommended to start with significantly lower dosages than one would take for either substance individually.
Anecdotal reports which describe the effects of this compound within our experience index include:
Additional experience reports can be found here:
Natural plant sources
Although LSA is illegal in some countries, various seeds which contain it are readily available in many gardening stores. However, the seeds from commercial sources are often coated in some form of pesticide or methylmercury which can result in extreme nausea and bodily discomfort if ingested. Methods for cleaning or de-coating the seeds are available, but are typically ineffective. Typically, the seeds have a earthy, dirt-like taste that can linger. Seeds that have any other flavor should be spit out so as to avoid hazardous coatings. The seed types listed below can be purchased without pesticide coatings online.
Morning glory seeds (MGS)
The seeds of many species of morning glory are known to contain lysergamide alkaloids such LSA.  Typical oral doses of morning glory seeds are as follows:
- Threshold:20 – 50 seeds / 1.5 g
- Light:50 – 100 seeds / 1.5 – 3 g
- Common:100 – 250 seeds / 3 – 6 g
- Strong:250 – 400 seeds / 6 – 10 g
- Heavy:400 seeds + / 10 g +
Hawaiian baby woodrose seeds (HBWR)
Hawaiian baby woodrose is a perennial climbing vine that is native to the Indian subcontinent and has since been introduced to numerous areas worldwide including Hawaii, Africa and the Caribbean. Its seeds may be consumed for their various lysergamide alkaloids such as LSA.  Typical oral doses for Hawaiian baby woodrose seeds are as follows:
- Threshold:1 – 3 seeds
- Light:3 – 5 seeds
- Common:5 – 7 seeds
- Strong:7 – 12 seeds
- Heavy:12 seeds +
LSA containing seeds can be prepared using a number of methods. Some of these methods are listed in our tutorial index and include:
Toxicity and harm potential
This toxicity and harm potential section is a stub.
As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it.
We also recommend that you conduct independent research and use harm reduction practices when using this substance.
The toxicity and long-term health effects of recreational LSA use have not been studied in any scientific context and the exact toxic dose is unknown.
Anecdotal evidence suggests that there are no negative health effects attributed to simply trying LSA by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use harm reduction practices when using this substance.
LSA should not be used regularly for long periods of time. When used repeatedly over a short period of time, LSA’s vasoconstrictive effects build up while the psychoactive effects get weaker. A common sign of vasoconstriction build up can be described as a feeling of painful or uncomfortable legs.  This happens as a result of an insufficient amount of blood getting to the muscles. The upper leg muscles are the largest, most energy consuming muscles in the body and will feel sore if blood flow to them is lowered even slightly.
When HBWR, morning glory seeds or pure LSA seeds are consumed and sore legs are experienced, a break has been reported to be helpful. With LSA it can take up to 3 days of abstinence to get back to vasoconstriction baseline.
Dependence and abuse potential
LSA is considered to be non-addictive with a low abuse potential. There are no literature reports of successful attempts to train animals to self-administer LSA, an animal model predictive of abuse liability, indicating that it does not possess the necessary pharmacology to either initiate or maintain dependence. [ citation needed ] There is virtually no withdrawal syndrome when use is stopped.
Tolerance to the effects of LSA forms almost immediately after ingestion. After that, it takes about 7 days for the tolerance to return to baseline (in the absence of further consumption). LSA produces cross-tolerance with all psychedelics, meaning that after the use of LSA all psychedelics will have a reduced effect.
Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations (although it cannot be guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.
- Lithium – Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
- Cannabis – Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of LSA. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
- Stimulants – Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis. 
- Tramadol – Tramadol is well-documented to lower the seizure threshold  and psychedelics may act to trigger seizures in susceptible individuals. 
Lysergic acid amide (also known as ergine, d-lysergic acid amide, d-lysergamide, and LSA) is a naturally-occurring psychedelic substance of the lysergamide class. LSA is an ergot alkaloid and the main psychoactive constituent of morning glory seeds. LSA is chemically related to LSD and is said to produce similar effects, although the extent to which it does is unclear.
Hawaiian Baby Woodrose
What other names is Hawaiian Baby Woodrose known by?
Argyreia nervosa, Argyreia speciosa, Baby Hawaiian Woodrose, Baby Woodrose, Bidhara, Convolvulus nervosus, Convolvulus speciosus, Elephant Climber, Elephant Creeper, Lettsomia nervosa, Liane d’Argent, Rose des Bois, Silver-Morning-Glory, Vidhara, Vriddadaru, Vridhadaru, Wood-Rose, Woolly Morning Glory.
What is Hawaiian Baby Woodrose?
Hawaiian baby woodrose is an ornamental plant that is related to the morning glory plant. It grows in Florida, California, and Hawaii. The seeds are used to make medicine.
Despite serious safety concerns, Hawaiian baby woodrose is used for pain relief and causing sweating.
But its more famous use is as a hallucinogen. Internet sellers promote Hawaiian baby woodrose as a “natural LSD.” The hallucinatory effects of Hawaiian baby woodrose are similar to alcohol intoxication with psychedelic visual effects such as enhanced colors. The effects last 6-8 hours.
Insufficient Evidence to Rate Effectiveness for.
- Pain relief.
- Causing sweating.
- Other conditions.
More evidence is needed to rate the effectiveness of Hawaiian baby woodrose for these uses.
How does Hawaiian Baby Woodrose work?
There isn’t enough information to know how Hawaiian baby woodrose works as a medicine.
Are there safety concerns?
Hawaiian baby woodrose is UNSAFE. It can cause side effects such as nausea, vomiting, dizziness, hallucinations, blurred vision, dilated pupils, rapid movement of eyeballs, sweating, fast heart rate, and increased blood pressure.
Special Precautions & Warnings:
Pregnancy and breast-feeding: It’s UNSAFE to use Hawaiian baby woodrose if you are pregnant or breast-feeding. Don’t use it.
Mental illness: Hawaiian baby woodrose has effects similar to the hallucinogen LSD. There is a concern that people with psychotic tendencies might have more severe reactions to using it.
Surgery: Hawaiian baby woodrose might affect levels of a brain chemical called serotonin. Because serotonin has powerful effects on the central nervous system and blood vessels, there are concerns that Hawaiian baby woodrose might interfere with surgery. Stop using Hawaiian baby woodrose at least 2 weeks before a scheduled surgery.
Are there any interactions with medications?
Hawaiian baby woodrose increases a brain chemical called serotonin. Some medications for depression also increase the brain chemical serotonin. Taking Hawaiian baby woodrose along with these medications for depression might increase serotonin too much and cause serious side effects including heart problems, shivering, and anxiety. Do not take Hawaiian baby woodrose if you are taking medications for depression.
Medications for depression (MAOIs)Interaction Rating: Major Do not take this combination.
Hawaiian baby woodrose increases a chemical in the brain. This chemical is called serotonin. Some medications used for depression also increase serotonin. Taking Hawaiian baby woodrose with these medications used for depression might cause there to be too much serotonin. This could cause serious side effects including heart problems, shivering, and anxiety.
Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.
Clozapine (Clozaril)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Clozapine (Clozaril) affects the brain. Hawaiian baby woodrose also affects the brain. Taking clozapine (Clozaril) along with Hawaiian baby woodrose might decrease the effects of Hawaiian baby woodrose.
CyproheptadineInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Cyproheptadine can affect the brain. Hawaiian baby woodrose might also affect the brain. But cyproheptadine affects the brain differently than Hawaiian baby woodrose. Taking cyproheptadine along with Hawaiian baby woodrose might decrease the effects of Hawaiian baby woodrose.
Dextromethorphan (Robitussin DM, and others)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Hawaiian baby woodrose can affect a brain chemical called serotonin. Dextromethorphan (Robitussin DM, others) can also affect serotonin. Taking Hawaiian baby woodrose along with dextromethorphan (Robitussin DM, others) might cause too much serotonin in the brain and serious side effects including heart problems, shivering, and anxiety. Do not take Hawaiian baby woodrose if you are taking dextromethorphan (Robitussin DM, and others).
Meperidine (Demerol)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Hawaiian baby woodrose increases a chemical in the brain called serotonin. Meperidine (Demerol) can also increase serotonin in the brain. Taking Hawaiian baby woodrose along with meperidine (Demerol) might cause too much serotonin in the brain and serious side effects including heart problems, shivering, and anxiety.
Pentazocine (Talwin)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Hawaiian baby woodrose increases a brain chemical called serotonin. Pentazocine (Talwin) also increases serotonin. Taking Hawaiian baby woodrose along with pentazocine (Talwin) might increase serotonin too much. This could cause serious side effects including heart problems, shivering, and anxiety. Do not take Hawaiian baby woodrose if you are taking pentazocine (Talwin).
Risperidone (Risperdal)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Taking risperidone (Risperdal) along with Hawaiian baby woodrose might decrease the effects of Hawaiian baby woodrose.
Tramadol (Ultram)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Tramadol (Ultram) can affect a chemical in the brain called serotonin. Hawaiian baby woodrose can also affect serotonin. Taking Hawaiian baby woodrose along with tramadol (Ultram) might cause too much serotonin in the brain and side effects including confusion, shivering, stiff muscles, and other side effects.
Dosing considerations for Hawaiian Baby Woodrose.
The appropriate dose of Hawaiian baby woodrose depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Hawaiian baby woodrose. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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Al-Assmar SE. The seeds of the Hawaiian baby woodrose are a powerful hallucinogen. Arch Intern Med 1999;159:2090.
Shawcross WE. Recreational use of ergoline alkaloid from Argyreia nervosa. J Psychoactive Drugs 1983;15:251-9.
Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. View abstract.
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Hawaiian Baby Woodrose What other names is Hawaiian Baby Woodrose known by? Argyreia nervosa, Argyreia speciosa, Baby Hawaiian Woodrose, Baby Woodrose, Bidhara, Convolvulus nervosus,