morning glory seed dosage

Morning glory seed dosage

Morning Glory is a common name of the family of plants known by the botanical name Convolvulaceae. Morning Glory is also the name given to a group of over one thousand different species of plants in the same family, based on similar characteristics.

Although most of the plants in the Convolvulaceae family are in the morning glory group, there are some plants in the family that are not. All members of the group known as morning glory plants are part of the Convolvulaceae family, but they are found in different genera.

Ipomoea is the largest genus in the Convolvulaceae family, it is made up of over 500 species of plants. The information on this page is about the morning glory plants in the genus Ipomoea that have seeds that are utilized for psychoactive purposes.

Classification Of Ipomoea
Domain: Eukarya
Kingdom: Plantae
Division: Magnoliophyta
Class: Magnoliopsida
Order: Solanales
Family: Convolvulaceae
Genus: Ipomoea

The members of the genus Ipomoea discussed below are indigenous to tropical areas of the globe, most notably Mexico and other parts of Central America. They are cultivated by gardeners in various parts of the world that have warm summers.

Although some members of the genus are shrubs or small trees, most are classified as vines. The species that are mentioned on this page and contain psychoactive compounds are all considered vines.

Gardeners almost always start these plants from seed. The vines prefer somewhat alkaline soil, ample amounts of water, moist soil that is well drained, warm temperatures with lots of sunlight.

Chemistry Of Ipomoea spp.

For centuries in Mexico and other parts of Central America, Ipomoea seeds have been utilized for mystical purposes. The power of Ipomoea tricolor seeds was known to the Aztecs, who called them tlitliltzin.

Most of the plants referred to as morning glory are not psychoactive, but there are plants in the Ipomoea genus that are. They produce seeds with fairly large concentrations of ergot alkaloids.

The primary ergot alkaloids in the seeds include:
— LSA (d-lysergic acid amide), aka ergine
— LAH (d-lysergic acid hydroxyethylamide) aka LSH
— ergometrine (d-lysergic acid beta-propanolamide)
— chanoclavine
— elymoclavine (reference 1)

Species that are thought to contain the largest concentrations of ergot alkaloids include:
Ipomoea purpurea
Ipomoea tricolor
Ipomoea violacea

There is a rare chance of fatal overdose after ingesting large amounts of seeds, or for someone who is sensitive to the chemicals present. High doses cause death from respiratory arrest.

In cases where overdose is life threatening;
— Empty contents of stomach.
— Administer sodium sulphate and medicinal charcoal.
— Electrolyte substitution.
— Check acidosis.
— Provide intubation and oxygen respiration for respiratory arrest or paralysis. (reference 2)

Availability Of Ipomoea spp.

If you are interested in cultivating your own plants or want to obtain seeds for medical, or some other purpose, you might be able to find morning glory seeds at a local nursery.

The Ipomoea strains listed below are the ones with seeds that are known to contain high concentrations of psychoactive chemicals:
— heavenly blue
— crimson rambler
— flying saucers
— pearly gates
— blue star

When compared to other seeds with similar chemistry, like hawaiian baby woodrose and ololiuqui, morning glory seeds often cost less per dose. But depending on where you live, this might not be the case.

Seeds will retain their original potency for about a year when stored in a dark place that is dry and cool. After about a year, they will start to lose strength but can still be ingested.

Ipomoea spp. Seed Dose Size

In most parts of the globe buying and selling morning glory seeds is legal for horticultural and most other similar applications.

However, depending on where you live it may be illegal to distribute or obtain morning glory seeds with the intent of consuming them as a drug.

In some countries, including the USA, it is illegal to extract the psychoactive ergot alkaloids from morning glory and other sources of the chemical alkaloids.

Although rare, an overdose can cause death. Bad judgement while under the influence may cause a person to perform and act that might be fatal.

For example driving a car after ingesting morning glory seeds might cause a person to react in such a manner as to cause fatalities to oneself or others.

Suicide while under the influence of morning glory seeds is also possible. This should be a concern for people in a negative mood or those with mental health issues.

The first time you try morning glory seeds, no more than 50-100 seeds are recommended. If 50-100 seeds proves unsatisfactory, increase the dose size by 50-100 seed each time you try until you find a dose size you are comfortable with.

Wait for at least a week between attempts and always have a sitter, someone who is not taking drugs to look after the situation, present. 50-100 seeds is a relatively small dose and many people will feel nothing.

200-400 morning glory seeds is the dose range most people consider moderate to strong. 200 seeds may be enough to produce satisfactory results for some people, while others may require up to 400 seeds to obtain the same results.

But like LSD, depending on the individual the effects of even small amounts of morning glory seeds can be extreme. The maximum recommended dose is 500 seeds for someone who has tried lower dose amounts but found they were not strong enough.

If 500 morning glory seeds doesn’t do anything for you, chances are the seeds you have are no good, or for some reason your body doesn’t respond to the active chemicals.

Never take more than 200 seeds at a time unless you have worked your way up to that dosage by increasing your dose by 50-100 seeds each new attempt. For most people 200-400 seeds are enough for a very deep experience, hallucinations are common at this level.

Effects are similar to LSD, although more sedating and not as intense. However, some people that have tried drugs like LSD and mushrooms report that to them the seeds produce a deeper experience.

As with LSD, good and bad experiences are possible. The best way to ensure positive results is pay attention to proper set and setting. Consume while in a good frame of mind with people you trust in a safe location.

A common way to consume the seeds is to grind them into small pieces with a coffee grinder, hammer, mortar and pestle, pepper mill, or something similar, mixing with water or drinking alcohol and stirring occasionally for 60 minutes or more, then drinking.

Some people put the crushed seeds in water or alcohol and let them sit in a cool and dark area for 1-7 days stirring occasionally before consumption. They filter out the seeds themselves and just drink the water or alcohol.

The water can be mixed with fruit juice concentrate or something similar to make it more palatable. Dry seeds can also be ground up and put in gelatin capsules or chewed for a while and swallowed.

People will sometimes try extraction as a means obtaining the active chemicals present in the seeds, while leaving less desirable compounds out of the mix.

On an empty stomach the effects can start to be felt in 15-30 minutes, nausea is common at the beginning but often subsides as time passes. In most cases the peak effects will start to be felt in about 60-180 minutes.

However, some people might not start to peak until more than 180 minutes after ingestion. After they start, the peak will usually last for 4-6 hours. Some people can peak for 12 hours or more.

When you start to feel the effects kick in, smoking some marijuana can really set things into motion. In some cases marijuana also helps settle the stomach and reduce nausea.

Small to moderate doses can be enlightening or mind opening experiences that have similarities to ingesting LSD. Larger doses can be alarming and frightening to some people.

Nausea, sleepiness, feeling like you are in a dream, inability to concentrate or think clearly, visual phenomena including hallucinations are common.

Potency may vary between different batches of seeds depending on such things as growing conditions, storage conditions, how old they are, as well as other factors.

Do not assume that because a certain number of seeds from one batch produced results you like that the same number of seeds from another batch will do the same.

Like hawaiian baby woodrose and ololiuqui seeds that contain similar chemicals, morning glory seeds should not taken by pregnant women because they may cause a miscarriage.

Be cautious and start with a small dose your first time. To reduce the chances of a negative experience only consume the seeds with people you trust in an environment where you feel comfortable.

Related Books

The Encyclopedia of Psychoactive Plants
Reference work about almost every common, and most less common plants and fungi, that humans have used to alter perception, mood, or consciousness. Includes history, distribution, cultivation, preparation, dosage.

Over 900 pages of easy to understand text with hundreds of full color photographs and b&w illustrations. This is the most thorough psychoactive plant encyclopedia available at the present time. Contains 4 pages about Ipomoea violacea and another 4 pages about other species in the genus.
The Encyclopedia of Psychoactive Plants

Mind-Altering And Poisonous Plants Of The World
First section of the book is an introduction. Second section covers over 200 psychoactive plants and fungi, one page per. Discusses active ingredients, toxicity, pharmacological effects, first aid, more.

First two sections are fairly easy for an intelligent layperson to comprehend. Third section concerns the chemistry of psychoactive plants, and would be of most use to those with at least some knowledge of the subject.

Over 450 pages, glossary, further reading, index. Has one page dedicated to Ipomoea tricolor, and two pages about the chemistry of ergot alkaloids that some plants and fungi produce.
Mind-Altering And Poisonous Plants Of The World

The chemistry and uses of morning glory seeds.

Morning glory seed dosage

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

⇣ Oral
Total 5 – 10 hours
Onset 30 – 180 minutes
Peak 2 – 7 hours
Offset 1 – 3 hours
After effects 3 – 24 hours

DISCLAIMER: PW’s dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Lysergic acid amide (also known as ergine, d-lysergic acid amide, d-lysergamide, and LSA) is a naturally-occurring psychedelic substance of the lysergamide class. LSA is an ergot alkaloid and the main psychoactive constituent of morning glory seeds. [ citation needed ] LSA is chemically related to LSD and is said to produce similar effects, although the extent to which it does is unclear.

LSA was first described in 1932 as part of an investigation into the alkaloids found in ergot. [1] In 1947, it was synthesized and tested for human activity by Albert Hofmann. The intramuscular administration of a 500 microgram dose produced a “tired, dreamy state with an inability to maintain clear thoughts.” [2] In 1970, LSA was detected as a constituent in Hawaiian baby woodrose seeds, which were being ground up into capsules and sold on the street as “mescaline”. [3] Today, LSA is typically consumed via morning glory and Hawaiian baby woodrose seeds. [4]

User reports describe the effects of LSA as primarily sedating and dream-like, with a mild to moderate psychedelic component. The psychedelic effects of LSA occur inconsistently and are not directly comparable to the effects of classical psychedelics like LSD, psilocybin mushrooms, or mescaline. LSA is described as primarily bodily and cognitive with little visual effects. Many users report serious nausea and bodily discomfort (“body load”) when taking LSA-containing seeds.

Like other psychedelics, LSA is not considered to be addictive. [5] However, adverse reactions such as severe anxiety, paranoia, and psychosis are always possible, particularly among those who are predisposed to psychiatric disorders. [6] It is therefore highly advised to use harm reduction practices if using this substance.


  • 1 Chemistry
  • 2 Pharmacology
  • 3 Subjective effects
    • 3.1 Physical effects
    • 3.2 Visual effects
      • 3.2.1 Enhancements
      • 3.2.2 Distortions
      • 3.2.3 Geometry
      • 3.2.4 Hallucinatory states
    • 3.3 Cognitive effects
    • 3.4 Auditory effects
    • 3.5 Transpersonal effects
    • 3.6 Combination effects
    • 3.7 Experience reports
  • 4 Natural plant sources
    • 4.1 Morning glory seeds (MGS)
    • 4.2 Hawaiian baby woodrose seeds (HBWR)
    • 4.3 Preparation methods
  • 5 Toxicity and harm potential
    • 5.1 Vasoconstriction
    • 5.2 Dependence and abuse potential
    • 5.3 Dangerous interactions
    • 5.4 Other interactions
  • 6 Legal status
  • 7 See also
  • 8 External links
    • 8.1 Discussion
  • 9 References


LSA, or d-lysergic acid amide, is an organic alkaloid belonging to the lysergamide class. The chemical structure of LSA contains a core structure of lysergic acid with an amine functional group bound to RN. The structure of lysergic acid is composed of a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline, an acetamide group is bound. LSA is additionally substituted at carbon 6 with a methyl group.

LSA is a chiral compound with two stereocenters at R5 and R8. LSA, also called (+)-D-LSA, has an absolute configuration of (5R, 8R). The three other stereoisomers of LSA do not have psychoactive properties. LSA is structurally analogous to LSD, with the exception being that LSA lacks the diethyl substitution of LSD at RN of its carboxamide group. It can be used as a precursor to LSD.


LSA’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience remains the subject of scientific investigation.

The notion that LSA is the primary psychedelic constituent in morning glory and Hawaiian baby woodrose seeds has been challenged as the effects of isolated synthetic LSA are reported to be only slightly psychedelic in nature. Therefore, it has been proposed that the overall experience may possibly be produced by a mixture of various lysergamide alkaloids (including iso-LSA and LSH) within these plant materials instead of a single psychoactive compound.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a literature based on anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be treated with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses are more likely to induce the full spectrum of effects. Likewise, adverse effects become much more likely with higher doses and may include serious injury or death.

Physical effects

    • Sedation – LSA is predominantly sedating; however, this can be setting dependent. For example, when taken in settings with large amounts of stimuli or during physically strenuous activities such as walking, running, climbing or dancing, LSA is capable of becoming stimulating and energetic. In contrast, when taken in calm environments such as darkened rooms with comfortable seating, it tends to be relaxing, sedating.
    • Spontaneous bodily sensations – The “body high” of LSA can be described as a mild yet pleasurable and soft tingling sensation. This is largely noticed in high doses and is accompanied by strong waves of physical euphoria which are usually manifested spontaneously at different unpredictable points throughout the trip but can also maintain a consistent presence. Compared to LSD, the physical effects of LSA tend to predominate the experience relative to its visual and cognitive effects.
      • Perception of bodily heaviness
      • Physical euphoria – This effect is reported to be more readily able to be produced by LSA than LSD. However, it can be masked by strong, uncomfortable feelings of nausea and vasoconstriction, particularly when LSA-containing seeds are consumed directly before any extraction has been performed.
    • Motor control loss – This effect becomes far more present at high doses than lower doses. It can be compared to the loss of motor control experienced with alcohol-induced inebriation and is strengthened by the perception of bodily heaviness.
    • Temperature regulation suppression [citation needed]
    • Nausea – The nauseating effects of LSA is thought to be mostly caused by the other components of the seeds (e.g. morning glory, Hawaiian baby woodrose, etc.) and not LSA itself. Various extraction methods can be used to significantly reduce if not eliminate the nausea that can be produced by this substance. Anecdotal reports also suggest that ginger tea or cannabis may be helpful in counteracting nausea.
    • Vasoconstriction [citation needed] – LSA is commonly reported to produce strong and pronounced feelings of vasoconstriction. This varies in its intensity between individuals but is often considered moderately to extremely uncomfortable in comparison to other psychedelics. This effect is commonly reported to cause joint and limb pains.
    • Increased heart rate
    • Increased blood pressure or Decreased blood pressure [citation needed] – LSA has been reported as being capable of producing both an increase and a decrease in blood pressure, sometimes alternating at different points in the experience, such as during the come up or offset, although it is unclear how much of this is dependent on the seeds and variations in alkaloid contents.
    • Muscle contractions & Muscle relaxation
    • Muscle spasms
    • Dehydration
    • Dizziness
    • Headaches [citation needed]
    • Appetite suppression
    • Gustatory enhancement
    • Orgasm suppression
    • Excessive yawning
    • Pupil dilation
    • Photophobia
    • Increased perspiration
    • Difficulty urinating

Visual effects

  • The visual effects of LSA are mostly present when large doses have been consumed. When compared to LSD and psilocin, the visual effects of LSA are proportionally mild in comparison to the intensity of its accompanying cognitive and physical effects.
  • Colour enhancement
  • Pattern recognition enhancement
  • Visual acuity enhancement
  • Frame rate enhancement

The visual distortions and alterations are significantly more simplistic than open eye distortions found with other psychedelics. The effects experienced are detailed below:

  • Depth perception distortions
  • Drifting(melting, breathing, morphing and flowing) – In comparison to other psychedelics, this effect can be described as mild but highly detailed and cartoon-like in appearance. The distortions are fast yet smooth in motion and fleeting in permanence. This is an inconsistently manifested effect with some people never reporting such effects.
  • Colour shifting
  • Tracers
  • Scenery slicing
  • Symmetrical texture repetition

The visual geometry produced by LSA can be described as more similar in appearance to that of 4-AcO-DMT and ayahuasca than LSD or 2C-B. It can be described through its variations as primarily intricate in complexity, abstract in form, organic in appearance, unstructured in organization, dimly lit, multicolored in scheme, glossy in shading, soft in edges, small in size, slow in speed, smooth in motion, rounded in corners, non-immersive in depth and consistent in intensity. At higher doses, it is significantly more likely to produce 8B geometry over 8A geometry.

Hallucinatory states

LSA is capable of consistently producing a full range of high-level hallucinatory states when it is taken in large doses. However, the doses required to achieve these states are likely to produce very uncomfortable, and potentially dangerous, side effects. These states include:

  • Transformations – These are extremely common within LSA and partially follow the content of the user’s current thought process.
  • Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) – Unlike LSD, LSA consistently produces moderate to high level hallucinatory states in high doses. This particular effect can be compared to a lucid dream state. The hallucinations are more common within dark environments and can be comprehensively described through their variations as lucid in believability, interactive in style, new experiences in content, controllable and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
  • External hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) – This effect occurs far more rarely and infrequently than with other hallucinogens. However, they can occasionally occur at heavier dosages. They can be described through their variations as lucid in believability, autonomous in controllability, and solid in style.
  • Peripheral information misinterpretation

Cognitive effects

  • The cognitive effects of LSA are described by many as extremely relaxing yet lucid and clear-headed in style when compared to other commonly used psychedelics such as LSD or psilocin. Although it is primarily sedating, it can produce fast-paced bursts of thought and stimulation at random intervals. LSA produces a large number of psychedelic cognitive effects. The most prominent of these typical effects include:
    • Analysis enhancement – This effect is introspection dominant.
    • Anxiety or Anxiety suppression
    • Conceptual thinking
    • Cognitive euphoria
    • Déjà vu
    • Delusion
    • Emotion enhancement
    • Empathy, affection and sociability enhancement
    • Increased music appreciation – Listening to music can strongly intensify the overall experience.
    • Immersion enhancement
    • Language suppression – Mild compared to language suppression on classical psychedelics like LSD.
    • Increased sense of humor
      • Laughter fits
    • Memory suppression
      • Ego death
    • Mindfulness
    • Novelty enhancement
    • Rejuvenation
    • Autonomous voice communication
    • Thought acceleration
    • Thought connectivity
    • Thought loops
    • Time distortion
    • Wakefulness

Auditory effects

    • Auditory enhancement
    • Auditory distortion
    • Auditory hallucinations

Transpersonal effects

    • Spirituality enhancement
    • Existential self-realization – This effect is less common and reproducible than it is with classical psychedelics like LSD, psilocybin mushrooms, and mescaline.
    • Unity and interconnectedness

Combination effects

  • Cannabis – Cannabis can immensely intensify the sensory and cognitive effects of LSA. Extreme caution is advised when mixing these substances as it can significantly increase the chances of a negative psychological reaction like anxiety, confusion and psychosis. Those who use this combination are advised to start off with only a fraction of their usual cannabis dose and take long breaks between hits in order to avoid a negative reaction.
  • Dissociatives – Dissociatives greatly enhance the cognitive, visuals and general hallucinatory effects of LSA. Dissociative-induced holes, spaces, and voids while under the influence of LSA have significantly more vivid visuals than dissociatives alone, as well as more intense internal hallucinations and correspondingly increased risk of confusion, delusions and psychosis.
  • Alcohol – Alcohol’s central depressant effects can be used to reduce some of the anxiety and tension produced by LSA. However, alcohol can cause dehydration, nausea and physical fatigue which can significantly worsen the experience. If using alcohol, it is advised to pace oneself and drink just a fraction of the usual amount.
  • Benzodiazepines – Depending on the dose, benzodiazepines can slightly to completely reduce the intensity of the cognitive, physical and visual effects of an LSA trip. They are very efficient at stopping “bad trips” at the cost of amnesia and reduced trip intensity. Caution is advised when acquiring them for this purpose as they are very easy to abuse.
  • Psychedelics – When used in combination with other psychedelics, each substance’s physical, cognitive and visual effects intensify and synergize strongly. The synergy between those substances is unpredictable, and for this reason generally not advised. If choosing to combine psychedelics, it is recommended to start with significantly lower dosages than one would take for either substance individually.

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Additional experience reports can be found here:

Natural plant sources

Although LSA is illegal in some countries, various seeds which contain it are readily available in many gardening stores. However, the seeds from commercial sources are often coated in some form of pesticide or methylmercury which can result in extreme nausea and bodily discomfort if ingested. Methods for cleaning or de-coating the seeds are available, but are typically ineffective. Typically, the seeds have a earthy, dirt-like taste that can linger. Seeds that have any other flavor should be spit out so as to avoid hazardous coatings. The seed types listed below can be purchased without pesticide coatings online.

Morning glory seeds (MGS)

The seeds of many species of morning glory are known to contain lysergamide alkaloids such LSA. [7] Typical oral doses of morning glory seeds are as follows:

  • Threshold:20 – 50 seeds / 1.5 g
  • Light:50 – 100 seeds / 1.5 – 3 g
  • Common:100 – 250 seeds / 3 – 6 g
  • Strong:250 – 400 seeds / 6 – 10 g
  • Heavy:400 seeds + / 10 g +

Hawaiian baby woodrose seeds (HBWR)

Hawaiian baby woodrose is a perennial climbing vine that is native to the Indian subcontinent and has since been introduced to numerous areas worldwide including Hawaii, Africa and the Caribbean. Its seeds may be consumed for their various lysergamide alkaloids such as LSA. [8] Typical oral doses for Hawaiian baby woodrose seeds are as follows:

  • Threshold:1 – 3 seeds
  • Light:3 – 5 seeds
  • Common:5 – 7 seeds
  • Strong:7 – 12 seeds
  • Heavy:12 seeds +

Preparation methods

LSA containing seeds can be prepared using a number of methods. Some of these methods are listed in our tutorial index and include:

Toxicity and harm potential

This toxicity and harm potential section is a stub.

As such, it may contain incomplete or even dangerously wrong information. You can help by expanding or correcting it.
We also recommend that you conduct independent research and use harm reduction practices when using this substance.

The toxicity and long-term health effects of recreational LSA use have not been studied in any scientific context and the exact toxic dose is unknown.

Anecdotal evidence suggests that there are no negative health effects attributed to simply trying LSA by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.


LSA should not be used regularly for long periods of time. When used repeatedly over a short period of time, LSA’s vasoconstrictive effects build up while the psychoactive effects get weaker. A common sign of vasoconstriction build up can be described as a feeling of painful or uncomfortable legs. [9] This happens as a result of an insufficient amount of blood getting to the muscles. The upper leg muscles are the largest, most energy consuming muscles in the body and will feel sore if blood flow to them is lowered even slightly.

When HBWR, morning glory seeds or pure LSA seeds are consumed and sore legs are experienced, a break has been reported to be helpful. With LSA it can take up to 3 days of abstinence to get back to vasoconstriction baseline.

Dependence and abuse potential

LSA is considered to be non-addictive with a low abuse potential. There are no literature reports of successful attempts to train animals to self-administer LSA, an animal model predictive of abuse liability, indicating that it does not possess the necessary pharmacology to either initiate or maintain dependence. [ citation needed ] There is virtually no withdrawal syndrome when use is stopped.

Tolerance to the effects of LSA forms almost immediately after ingestion. After that, it takes about 7 days for the tolerance to return to baseline (in the absence of further consumption). LSA produces cross-tolerance with all psychedelics, meaning that after the use of LSA all psychedelics will have a reduced effect.

Dangerous interactions

Although many psychoactive substances are reasonably safe to use on their own, they can quickly become dangerous or even life-threatening when combined with other substances. The list below includes some known dangerous combinations (although it cannot be guaranteed to include all of them). Independent research (e.g. Google, DuckDuckGo) should always be conducted to ensure that a combination of two or more substances is safe to consume. Some interactions listed have been sourced from TripSit.

  • Lithium – Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
  • Cannabis – Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of LSA. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
  • Stimulants – Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis. [citation needed]
  • Tramadol – Tramadol is well-documented to lower the seizure threshold [10] and psychedelics may act to trigger seizures in susceptible individuals. [citation needed]

Lysergic acid amide (also known as ergine, d-lysergic acid amide, d-lysergamide, and LSA) is a naturally-occurring psychedelic substance of the lysergamide class. LSA is an ergot alkaloid and the main psychoactive constituent of morning glory seeds.[citation needed] LSA is chemically related to LSD and is said to produce similar effects, although the extent to which it does is unclear.