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Genetic influences on muscle strength, lean body mass, and bone mineral density: a twin study

Affiliation

  • 1 Twin Research Unit, St. Thomas’ Hospital, London, United Kingdom.
  • PMID: 9421240
  • DOI: 10.1359/jbmr.1997.12.12.2076

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Genetic influences on muscle strength, lean body mass, and bone mineral density: a twin study

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Authors

Affiliation

  • 1 Twin Research Unit, St. Thomas’ Hospital, London, United Kingdom.
  • PMID: 9421240
  • DOI: 10.1359/jbmr.1997.12.12.2076

Abstract

Lean body mass and muscle strength are both associated with bone mineral density (BMD), which is known to be under strong genetic control. In this classical twin study, we examine the size of the genetic component of both muscle strength and lean body mass and to what degree they account for the genetic component of BMD. In all, 706 postmenopausal women were examined; 227 pairs of monozygous (MZ) twins and 126 pairs of dizygous (DZ) twins. Grip strength was measured using a hand-help grip bulb and leg strength using a dynamic leg extensor power rig. Lean body mass and BMD at multiple sites were measured by dual-energy X-ray absorptiometry. BMD correlated with both leg extensor strength (r = 0.16-0.26) and grip strength (r = 0.12-0.21). Lean mass was significantly correlated with BMD at all sites (r = 0.20-0.39). All three muscle variables have a moderate genetic component with heritability estimates of 0.52 for lean body mass, 0.46 for leg extensor strength, and 0.30 for grip strength (all p Flicker L, Hopper JL, Rodgers L, Kaymakci B, Green RM, Wark JD. Flicker L, et al. J Bone Miner Res. 1995 Nov;10(11):1607-13. doi: 10.1002/jbmr.5650101102. J Bone Miner Res. 1995. PMID: 8592936

Lean body mass and muscle strength are both associated with bone mineral density (BMD), which is known to be under strong genetic control. In this classical twin study, we examine the size of the genetic component of both muscle strength and lean body mass and to what degree they account for the gen …

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It’s with a heavy heart that I have to create this gofundme on behalf of Peter Molle, co-found… Don Ation needs your support for MASS GENETICS PETE LEGAL FUND