ibuprofen and weed

Drug Interactions between cannabis and ibuprofen

This report displays the potential drug interactions for the following 2 drugs:

  • cannabis
  • ibuprofen

Interactions between your drugs

No interactions were found between cannabis and ibuprofen. This does not necessarily mean no interactions exist. Always consult your healthcare provider.


A total of 377 drugs are known to interact with cannabis.

  • Cannabis is in the drug class illicit (street) drugs.
  • Cannabis is used to treat the following conditions:
    • AIDS Related Wasting
    • Muscle Spasm
    • Nausea/Vomiting, Chemotherapy Induced
    • Pain


A total of 357 drugs are known to interact with ibuprofen.

Drug and food interactions

cannabis (Schedule I substance) food

Applies to: cannabis

Alcohol can increase the nervous system side effects of cannabis (Schedule I substance) such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cannabis (Schedule I substance). Do not use more than the recommended dose of cannabis (Schedule I substance), and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See Also

  • Cannabis Drug Interactions
  • Ibuprofen Drug Interactions
  • Ibuprofen General Consumer Information
  • Drug Interactions Checker
Drug Interaction Classification
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some mixtures of medications can lead to serious and even fatal consequences.

View drug interactions between cannabis and ibuprofen. These medicines may also interact with certain foods or diseases.

Can One Pill Reduce the ‘Haze’ of Medical Marijuana Use?

Scientists discover how THC affects the brain and a common over-the-counter pill could reduce unwanted cognitive side effects.

Twenty U.S. states and the District of Columbia now allow for medical marijuana to be used as a treatment for a variety of medical conditions, from chronic pain to anxiety.

While the use of marijuana is becoming more widely accepted for medical purposes, it still has drawbacks, including learning and short-term memory problems. These side effects have been one of the major hurdles preventing medical marijuana’s wider adoption, and they’re one reason the American Medical Association (AMA) rejected a proposal earlier this week to take a more neutral stance on the full legalization of the drug.

But a new study published in the journal Cell shows there are ways to avoid the memory “haze” associated with using marijuana. Researchers say the solution may be as simple as looking into your medicine cabinet.

The main active ingredient in marijuana is Δ 9-tetrahydrocannabinol (THC). The U.S. Food and Drug Administration (FDA) has already approved drugs based on THC to treat nausea and vomiting in chemotherapy patients. The drugs aren’t approved for other uses, mainly due to additional side effects.

Chu Chen, professor of otorhinolaryngology and neuroscience at Louisiana State University’s School of Medicine, says that scientists now know how THC affects the body on the molecular level, so unwanted side effects can be reduced.

What’s the secret? Ibuprofen.

“Our studies have solved the longtime mystery of how marijuana causes neuronal and memory impairments,” Chen said in a press release. “The results suggest that the use of medical marijuana could be broadened if patients concurrently take a nonsteroidal anti-inflammatory drug such as ibuprofen.”

Chen and his team discovered that THC treatments increase the levels of an enzyme called cyclooxygenase-2 (COX-2) in the in a mouse’s hippocampus. The hippocampus is the part of the brain where memories are formed.

Coincidentally—or perhaps not—they also found that drugs that reduced the levels of COX-2 in the mice prevented the memory problems typically caused by repeated use to THC.

This makes Chen believe that an easy strategy to combat the short- and long-term memory effects of marijuana could be as easy as taking a few doses of ibuprofen.

There are currently no effective strategies to combat the destructive effects of Alzheimer’s disease in brain tissue. Studies have shown that even the best anti-dementia drugs can do nothing to halt the progressive nature of the disease.

But during the study, Chen says, the combination of THC and COX-2 was able to reduce the neuronal damage in mice genetically engineered to mimic Alzheimer’s disease.

“Our results suggest that the unwanted side effects of cannabis could be eliminated or reduced, while retaining its beneficial effects, by administering a COX-2 inhibitor along with Δ9-THC for the treatment of intractable medical conditions such as Alzheimer’s disease,” Chen said.

Scientists discover how THC affects the brain and a common over-the-counter pill could reduce unwanted cognitive side effects.