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The dopamine D2 receptor gene: a genetic risk factor in substance abuse

Affiliation

  • 1 Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010.
  • PMID: 8033754
  • DOI: 10.1016/0376-8716(94)90154-6

The dopamine D2 receptor gene: a genetic risk factor in substance abuse

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Authors

Affiliation

  • 1 Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010.
  • PMID: 8033754
  • DOI: 10.1016/0376-8716(94)90154-6

Abstract

Drug abuse has grown to epidemic proportions. Dopaminergic reward pathways have frequently been implicated in the etiology of drug addiction. To examine the possible role of genetic variants of the dopamine D2 (DRD2) gene in susceptibility to drug abuse we determined the prevalence of the TaqI A1 variant of the DRD2 gene in 200 white patients hospitalized in the Addiction Treatment Unit of a Veterans Administration Hospital. While the prevalence of the D2A1 allele was not significantly increased over controls, it did increase from 21% in subjects with alcohol abuse only to 32% in subjects with alcohol dependence only, consistent with other studies showing an association with the severity of alcoholism. By contrast, of 104 subjects with a discharge diagnosis of drug and alcohol abuse/dependence, 42.3% carried the D2A1 allele versus 29.0% of the 763 white controls (representing all white controls published to date) (P = 0.006). Of those who spent more than $25/week on two or more substances, 56.9% carried the D2A1 allele versus 28.2% of those abusing a single substance (P Blum K, Braverman ER, Wood RC, Gill J, Li C, Chen TJ, Taub M, Montgomery AR, Sheridan PJ, Cull JG. Blum K, et al. Pharmacogenetics. 1996 Aug;6(4):297-305. doi: 10.1097/00008571-199608000-00003. Pharmacogenetics. 1996. PMID: 8873216

Drug abuse has grown to epidemic proportions. Dopaminergic reward pathways have frequently been implicated in the etiology of drug addiction. To examine the possible role of genetic variants of the dopamine D2 (DRD2) gene in susceptibility to drug abuse we determined the prevalence of the TaqI A1 va …